Properties:

Product Name: Limonin

Characters: Yellow-brown or light yellow or white fine powder, easy-to-stripping ester of organic solvents, insoluble in water, soluble easily in methanol, ethanol solubility .
Molecular Formula: C₂₆H₃₀O₈
Molecular Weight: 470.53
Appearance: White fine powder

CAS No.: 1180-71-8
Specification: Limonin:95%,98% 

                       Hesperidin 90%  95% 98%

                       synephrine 5-30% 

                       Or 5:1 10: 1 20:1 

Packing: Packed in paper-drums and two plastic-bags inside or as per your request.
Net weight: 25kg/drum
Stored in a cool and dry well-closed container, keep away from moisture and strong light/heat.

Description:
Limonin is chemically related to triterpene derivatives found in the Rutaceae and Meliaceae families named limonoids. All naturally occurring citrus limonoids contain a furan ring attached to the D-ring, at C-17, as well as oxygen-containing functional groups at C-3, C-4, C-7, C-16, and C-17. Limonin contains a C-14, 15-epoxide group.
Limonin was studied as an abortifacient agent, amoebicidal substance, chemopreventive agents, and inhibitors of oral carcinogenesis. Therefore limonin may be a valuable chemical for carcinogen treatment or health enhancement.

Function and usage:
Limonin, nomilin, and nomilinic acid are the predominant limonoids in citrus fruits.
These limonoids exist in citrus fruit primarily in the form of glucosides. Unlike the aglycones, the limonoid glucosides (LG) are not bitter. Recent studies in Dr. Miller's laboratory at Baylor College of Dentistry have shown that limonoids and their corresponding glucosides are inhibitors of chemical carcinogenesis. Since the concentration of LG in orange juice and grapefruit juice is 320 and 190 ppm, respectively, the regular consumption of these products exposes the consumer to relatively high concentrations of these anticancer agents. Efforts to increase exposure to LG should increase the potential health benefits. Recently, a company in Japan formulated a test product, designated LG1000, in which the concentration of LG in a mandarin orange juice was increased from 200 to 1,000 ppm.
Anti-nociceptive and anti-inflammatory effects of limonin isolated from the dried fruits of Evodia rutaecarpa var. bodinieri were investigated. Oral administration of 30 or 100 mg/kg limonin significantly decreased the frequency of licking and biting behavior within a unit of time at the late phase without affecting that of the early phase in the formalin test. Limonin inhibited the rise of vascular permeability induced by acetic acid and the increase of paw edema induced by carrageenin. Limonin also showed inhibitory effects on bradykinin-induced paw edema and arachidonic acid-induced ear swelling. These results suggest that limonin possesses an antinociceptive effect and the effect may be accompanied by an anti-inflammatory action, and that the antinociceptive activity in Evodiae Fructus is partially attributable to limonin.